Research Progress of Genetic Modified Bone Marrow Mesenchymal Stem Cell Transplantation for the Therapy of Parkinson’s Disease
نویسندگان
چکیده
Parkinson’s disease (PD) is a neurodegenerative disease characterized by progressive degeneration of nigrostriatal dopaminergic (Dopamine, DA) neurons and reduced concentration of striatal dopamine. Traditional therapies for Parkinson’s disease are medication and surgery, while gene therapy and stem-cell therapy have been considered as much more ideal methods recently, such as embryonic stem cells, neural stem cells and mesenchymal stem cells, etc. Bone mesenchymal stem cells as a kind of pluripotent stem cells in the body are widely used in the related human diseases for the superiority to be the target cells of gene therapy. However, choosing appropriate target genes for therapy of Parkinson’s disease has a great diversity, therefore, here I summarize the researches of the theraphy methods of Parkinson’s disease in recent 10 years.
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